Experimental diabetes acutely reduces neural support of blood pressure in the SHR

ORCID

J. Mark Van Ness: https://orcid.org/0000-0001-5902-8735

Document Type

Article

Publication Title

FASEB Journal

Department

Health, Exercise, and Sport Sciences Department

ISSN

0892-6638

Volume

12

Issue

5

First Page

5699

Publication Date

1-1-1998

Abstract

We hypothesized that streptozotocin (STZ)-induced diabetes would reduce mean arterial pressure (MAP) in spontaneously hypertensive rats (SHR) within twenty-four hours. MAP, heart rate (HR), and neural support of MAP (depressor response to hexamethonium; 30 mg/kg) were determined from chronically instrumented male SHR prior to injection of either STZ (65 mg/kg iv) or vehicle (citrate buffer). STZ reduced MAP (-32±3 mmHg) and HR (-39±10 bpm) after only twenty-four hours. Forty-eight hours after STZ-treatment, neural support of MAP was significantly reduced (control: ΔMAP = -82±5 mmHg; STZ: ΔMAP = -57±6 mmHg). There was no evidence of hemoconcentration or reduced alpha-adrenergic responsiveness. The results are consistent with the hypothesis that STZ-induced diabetes acutely decreases MAP and neural support of MAP. We speculate that hypothalamic mechanisms involved in energy balance homeostasis may contribute to the observed reductions in sympathetic support of MAP produced by acute diabetes.

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