Thio-β-D-glucosides: synthesis and evaluation as glycosidase inhibitors and activators

Authors

Andrey V. Samoshin, University of the Pacific
Irina A. Dotsenko, University of the Pacific
Nataliya M. Samoshina, University of the Pacific
Andreas H. Franz, University of the PacificFollow
Vyacheslav V. Samoshin, University of the PacificFollow

Document Type

Article

Publication Title

International Journal of Carbohydrate Chemistry

Department

Chemistry

ISSN

1687-9341

Volume

2014

DOI

10.1155/2014/941059

First Page

1

Last Page

8

Publication Date

1-1-2014

Abstract

Structurally simple 1-thio-β-D-glucopyranosides were synthesized and tested as potential inhibitors toward several fungal glycosidases from Aspergillus oryzae and Penicillium canescens. Significant selective inhibition was observed for α- and β-glucosidases, while a weak to moderate activation for α- and β-galactosidases.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Samoshin, A. V., Dotsenko, I. A., Samoshina, N. M., Franz, A. H., & Samoshin, V. V. (2014). Thio-β-D-glucosides: synthesis and evaluation as glycosidase inhibitors and activators. International Journal of Carbohydrate Chemistry, 2014, 1–8. DOI: 10.1155/2014/941059
https://scholarlycommons.pacific.edu/cop-facarticles/135