Title

Optimization of doxorubicin-loaded anticancer liposomes with a pH-sensitive conformational switch

Lead Author Affiliation

Pharmaceutics and Drug Design

Introduction

Doxorubicin is an anthracyline drug widely used in clinical as a broad spectrum anti-cancer drug to treat several cancers. It intercalates between base pairs in the DNA helix and inhibit topoisomerase II, preventing DNA replication. However, cardiotoxicity and renal damage has limited its application. Thus, selective accumulation of doxorubicin at the tumor site becomes a critical step of better therapeutic outcome.

Location

DUC Ballroom A&B

Format

Poster Presentation

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Apr 30th, 1:00 PM Apr 30th, 3:30 PM

Optimization of doxorubicin-loaded anticancer liposomes with a pH-sensitive conformational switch

DUC Ballroom A&B

Doxorubicin is an anthracyline drug widely used in clinical as a broad spectrum anti-cancer drug to treat several cancers. It intercalates between base pairs in the DNA helix and inhibit topoisomerase II, preventing DNA replication. However, cardiotoxicity and renal damage has limited its application. Thus, selective accumulation of doxorubicin at the tumor site becomes a critical step of better therapeutic outcome.