Optimizing the structure of TTR Ligands for Half-life Extension (TLHE) of Peptides

Authors

Arindom Pal, University of the Pacific
Raghavendra Jampala, University of the Pacific
Mark Miller, University of the Pacific
Wabel Albusairi, University of the Pacific
Mamoun Alhamadsheh, University of the Pacific

Lead Author Affiliation

Pharmaceutics and Medicinal Chemistry

Introduction/Abstract

The tremendous therapeutic potential of peptides has not been fulfilled and potential peptide therapies that have failed far outnumber the successes so far. A major challenge impeding the more widespread use of peptides as therapeutics is their poor pharmacokinetic profile, due to short in vivo half-life resulting from inactivation by serum proteases and rapid elimination by kidneys.

Location

DUC Ballroom A&B

Format

Poster Presentation