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Date of Award

1984

Document Type

Thesis - Pacific Access Restricted

Degree Name

Master of Science (M.S.)

Department

Graduate School

First Advisor

Ravindra Vasavada

First Committee Member

Herschel Frye

Second Committee Member

Donald Barker

Abstract

In this study, lanolin alcohol as well as lanolin alcohol-povidone films (1:1 . 5) were investigated as a potential drug delivery system. The in vitro drug release from these films was studied in terms of the effect of agitation, film thickness and drug concentration. The rate of release of Cortisol from lanolin alcohol films was not affected by the intensity of agitation. Moreover, the film matrix was found to remain essentially intact throughout the release process. Further analysis of the data revealed that Higuchi's diffusion-controlled granular matrix model explained the mechanism of Cortisol release from such films. The results of drug release from lanolin alcohol povidone films have shown that although Higuchi's release rate constant was found to be independent of film thickness, it was affected by the intensity of agitation, since the rate constant was found to increase as agitation speed was increased, especially at low speeds. In addition, povidone was found to leach out of the film matrix along with the drug. These factors, in conjunction with further analysis of the drug, explained the failure of this film system to conform to the matrix-controlled diffusion model. The release rate of Cortisol from this film system was found to follow first-order dependence on drug concentration. The drug was found to be completely insoluble in lanolin alcohol, and slightly soluble in povidone. Povidone was found to enhance the solubility of Cortisol in water.

Pages

114

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