Campus Access Only
All rights reserved. This publication is intended for use solely by faculty, students, and staff of University of the Pacific. No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, now known or later developed, including but not limited to photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author or the publisher.
Date of Award
1984
Document Type
Thesis
Degree Name
Master of Science (M.S.)
Department
Graduate School
First Advisor
Ravindra Vasavada
First Committee Member
Herschel Frye
Second Committee Member
Donald Barker
Abstract
In this study, lanolin alcohol as well as lanolin alcohol-povidone films (1:1 . 5) were investigated as a potential drug delivery system. The in vitro drug release from these films was studied in terms of the effect of agitation, film thickness and drug concentration. The rate of release of Cortisol from lanolin alcohol films was not affected by the intensity of agitation. Moreover, the film matrix was found to remain essentially intact throughout the release process. Further analysis of the data revealed that Higuchi's diffusion-controlled granular matrix model explained the mechanism of Cortisol release from such films. The results of drug release from lanolin alcohol povidone films have shown that although Higuchi's release rate constant was found to be independent of film thickness, it was affected by the intensity of agitation, since the rate constant was found to increase as agitation speed was increased, especially at low speeds. In addition, povidone was found to leach out of the film matrix along with the drug. These factors, in conjunction with further analysis of the drug, explained the failure of this film system to conform to the matrix-controlled diffusion model. The release rate of Cortisol from this film system was found to follow first-order dependence on drug concentration. The drug was found to be completely insoluble in lanolin alcohol, and slightly soluble in povidone. Povidone was found to enhance the solubility of Cortisol in water.
Pages
114
Recommended Citation
Treki, Mahmud Sighayer. (1984). Release of cortisol from lanolin alcohol-providone films. University of the Pacific, Thesis. https://scholarlycommons.pacific.edu/uop_etds/480
Rights Statement
No Known Copyright. URI: http://rightsstatements.org/vocab/NKC/1.0/
The organization that has made the Item available reasonably believes that the Item is not restricted by copyright or related rights, but a conclusive determination could not be made. Please refer to the organization that has made the Item available for more information. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use.
