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Date of Award


Document Type


Degree Name

Master of Science (M.S.)


Graduate School

First Advisor

James C. King

First Committee Member

Madhukar Chaubal

Second Committee Member

Herschel G. Frye

Third Committee Member

Patrick Catania


In most hospitals today, plastic devices are replacing the traditional metal, glass and rubber. The increased use of polymeric materials as implanted prosthetic devices, catheters, disposable equipment and for the administration of blood, intravenous fluids and drugs has been widely accepted by the medical profession. This present study was designed to evaluate different types of plastics for potential use as large volume parenteral containers. Using several different therapeutic agents, a variety of plastic containers were examined for the possibility of the occurrence of drug-plastic interactions. The inclusion in the study of a commercially available plasticized product used for the administration of parenteral solutions was to compare the results of commercial products to non-commercial products.





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