Date of Award
2014
Document Type
Thesis - Pacific Access Restricted
Degree Name
Master of Science (M.S.)
Department
Pharmacy
First Advisor
Timothy J. Smith, R.Ph., Ph.D.
First Committee Member
John C. Livesey, Ph.D.
Second Committee Member
Linda L. Norton, Pharm.D.
Abstract
In addition to their potential value for in situ bioremediation, the earthworm as a laboratory model may offer insight into mechanisms of xenobiotic toxicity. Using the filter paper contact toxicity test, the LD50s of a series of salicylates and phenolics were determined. The rank order in toxicity of these chemicals was compared with mammalian (rat, oral dosing) LD50s and found to be similar. To determine if protein secretion from chemical stress would be a more sensitive toxicity marker for the above xenobiotics, worms were exposed to either sodium salicylate or acetaminophen at a no effect level (NOAEL) and at the LD100 through filter paper contact. The ability of L. terrestris to metabolize drugs was investigated by using worm homogenate to treat various drugs in both encapsulated and free enzyme forms.
Pages
35
Recommended Citation
Tang, Willie. (2014). Toxicity of Phenolics and Metabolism of their Esters in Lumbricus Terrestris. University of the Pacific, Thesis - Pacific Access Restricted. https://scholarlycommons.pacific.edu/uop_etds/4233
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