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Date of Award
1972
Document Type
Thesis
Degree Name
Master of Science (M.S.)
Department
Graduate Studies
First Advisor
Marvin H. Malone
First Committee Member
Donald Y. Shirachi
Second Committee Member
Charles W. Roscoe
Third Committee Member
Fuad M. Nahhas
Fourth Committee Member
Carl C. Riedesel
Abstract
Inflammation appears to be an attempt by the organism to re-establish homeostasis as a response to local reactive change in tissues following injury or irritation. This injury or irritation (whether caused by micro-organisms, toxins, antigens, etc.) first leads to an increased passage of fluid through the walls of the microvasculature, followed by stasis of circulation within the affected area. This, in turn, is followed by migration of leukocytes into the area and finally concluded by connective tissue proliferation leading to the deposition of granulation tissue.
There are many experimental models employed for the evaluation of drugs with possible anti-inflammatory activity. Since many of these systems employ whole animals, it seems rational that various hematological parameters could be applied. Our purpose was to test such parameters in two selected systems (i.e., adjuvant-induced arthritis and cotton pellet granuloma formation) during drug evaluation. The parameters under investigation included: total white blood cell count, differential leukocyte count, sedimentation rate and serum protein patterns.
Pages
126
Recommended Citation
Omaye, Stanley Teruo. (1972). Hematologic effects of cryogenine and certain selected anti-inflammatory agents. University of the Pacific, Thesis. https://scholarlycommons.pacific.edu/uop_etds/418
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