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Date of Award
Master of Science (M.S.)
Emerson G. Cobb
W. H. Wadman
It seems possible that efforts to discover essential chemical differences which might exist between normal and malignant cells will eventually reveal the secret of cancer and thereby lead to new approaches to safer and more selective chemotherapy.
One objective of this study is to find that part of this molecule that causes it to concentrate in the tumor and thence make a smaller size compound which has similar concentration characteristics to tumor as tetracycline. For this purpose, an attempt was made in this study to synthesize the right side ring of Chlorotetracycline, the structure of which is shown below. [see PDF]
Tomomatsu, Hideo. (1960). 3-amino-2,5-dihydroxy-5-sulfo-benzoic acid. University of the Pacific, Thesis. https://scholarlycommons.pacific.edu/uop_etds/367