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Antibradykinin Evaluation Of Cryogenine And Selected Other Agents

Author

Ralph William Trottier Jr., University of the Pacific

Date of Award

1971

Document Type

Dissertation

Degree Name

Doctor of Philosophy (Ph.D.)

Department

Graduate Studies

First Advisor

Marvin H. Malone

First Committee Member

Carl C. Riedesel

Second Committee Member

James R. Thompson

Third Committee Member

John K. Brown

Fourth Committee Member

Herschel G. Frye

Abstract

One intent of this study was to detect and to define any antibradykinin capacity that cryogenine may have using both in vivo and in vitro pharmacological models. The activity of cryogenine in these tests was compared to a variety of clinically-proven anti-inflammatory compounds as well as to other agents known to possess anti-inflammatory activity in certain experimentally-induced inflammations. Cryogenine is an unusual anti-inflammatory agent since it is an alkaloid - all of the commonly used anti-inflammatories (aspirin, phenylbutazone, indomethacin, etc.) are organic acids.

Pages

103

Recommended Citation

Trottier, Ralph William Jr.. (1971). Antibradykinin Evaluation Of Cryogenine And Selected Other Agents. University of the Pacific, Dissertation. https://scholarlycommons.pacific.edu/uop_etds/2914