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Observations Related To The Mechanisms Of Tetracycline-Induced Lipid Accumulation In A Strain Of Mouse Fibroblasts Cultivated In Vitro

Author

Dale William James, University of the Pacific

Date of Award

1971

Document Type

Dissertation

Degree Name

Doctor of Philosophy (Ph.D.)

Department

Graduate School

First Advisor

Donald M. Pace

First Committee Member

John K. Brown

Second Committee Member

Herschel Frye

Third Committee Member

Carl C. Riedesl

Abstract

Intravenous administration of tetracycline has been known to result in fatty degeneration of the liver. This study was undertaken in order to elucidate some of the actions of tetracycline on mammalian cells in culture and to attempt to relate these findings to the clinical condition of fatty degeneration of the liver mentioned above.

It is suggested that lipid accumulation occurring after tetracycline administration is possible the result of a decrease in B-lipoprotein synthesis and enzyme inhibition. These factors could result from the high blood levels of tetracycline seen after large and rapid intravenous injections of the drugs into normal patients or those suffering from kidney impairment.

Pages

127

Recommended Citation

James, Dale William. (1971). Observations Related To The Mechanisms Of Tetracycline-Induced Lipid Accumulation In A Strain Of Mouse Fibroblasts Cultivated In Vitro. University of the Pacific, Dissertation. https://scholarlycommons.pacific.edu/uop_etds/2875