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Date of Award
2001
Document Type
Dissertation - Pacific Access Restricted
Degree Name
Doctor of Philosophy (Ph.D.)
Department
Pharmaceutical and Chemical Sciences
First Advisor
Xiaoling Li
First Committee Member
Donald Floriddia
Second Committee Member
Arthur Harrelson
Third Committee Member
Patrick Jones
Fourth Committee Member
Bret Berner
Abstract
The objective of this research was to investigate two important aspects of buccal drug delivery, transport and mucoadhesion. Buspirone was chosen as a model drug for the in vitro buccal transport studies, polyvinyl alcohol and sodium alginate polymer blends were prepared to investigate the mucoadhesive properties through a Lewis acid-base approach and finally, the effect of formulation factors on the force of mucoadhesion, surface energy parameters, release rate and flux was studied. In vitro permeation studies were conducted to investigate the buccal transport pathway of buspirone. Mathematical models were developed to quantify the process of permeation. Permeation enhancement of buspirone across the buccal mucosa was investigated using bile salts (sodium glycocholate and taurodeoxycholate), propylene glycol, propylene. Effect of formulation factors like drug, enhancer, and plasticizer was studied through statistically designed experiments. These experiments aided in characterizing the buccal delivery system. Mathematical models were developed for surface energy parameters, force of mucoadhesion, release rate, and flux. Research conducted in this dissertation focused on two important aspects of transbuccal delivery, drug transport and mucoadhesion by studying a model drug and polymer blends. The results obtained in these investigations can be utilized in the development of other bioadhesive delivery systems with respect to drug transport and mucoadhesion. Polymer blends of polyvinyl alcohol (PVA) and sodium alginate (Alg) were prepared to evaluate their mucoadhesive properties and investigate mucoadhesive mechanism by a Lewis acid-base approach. (Abstract shortened by UMI.)
Pages
168
ISBN
9780493155043 , 049315504X
Recommended Citation
Birudaraj, Kondamraj. (2001). Transbuccal drug delivery: In vitro characterization of transport pathway of buspirone and bioadhesive drug delivery system. University of the Pacific, Dissertation - Pacific Access Restricted. https://scholarlycommons.pacific.edu/uop_etds/2733
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