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Date of Award
2009
Document Type
Dissertation - Pacific Access Restricted
Degree Name
Doctor of Philosophy (Ph.D.)
Department
Pharmaceutical and Chemical Sciences
First Advisor
Bhaskara Jasti
Second Advisor
Xiaoling Li
First Committee Member
Silvio Rodriguez
Second Committee Member
Wade Russu
Third Committee Member
Jayne Hastedt
Abstract
Molecular interactions of small molecules with polymers in solid state have numerous applications in pharmaceutical research. This dissertation examines the mechanism of the solid state interactions of the biologically active sulfamide derivatives with polyethylene glycol (PEG) and structurally related polymers. It is shown that in addition to the formation of the eutectic systems, PEG and related polymers cause polymorphic transitions of sulfamide derivatives. A new polymorphic form of a model sulfamate, topiramate, has been discovered and characterized using multiple analytical techniques. The phase diagrams describing the interactions of Topiramate with PEG and poloxamer block copolymer in solid state were constructed and the mechanism of the polymorphic transformations has been proposed. It was concluded that formation and stabilization of the new polymorphs occurred due to rearrangement of the hydrogen bonding networks of the sulfamide derivatives caused by the conformational changes of the polymer chains.
Pages
156
ISBN
9781109250558
Recommended Citation
Yam, Noymi. (2009). Molecular interactions of biologically active derivatives of sulfamide with pharmaceutical polymers in solid state. University of the Pacific, Dissertation - Pacific Access Restricted. https://scholarlycommons.pacific.edu/uop_etds/2398
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