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Date of Award


Document Type

Thesis - Pacific Access Restricted

Degree Name

Master of Science (M.S.)


Graduate Studies

First Advisor

Edward Avakian

First Committee Member

Marvin H. Malone

Second Committee Member

James W. Blankenship

Third Committee Member

Herschel Frye


In light of the limited and conflicting experimental data on food intake, body weight change and body energy metabolism following single-dose or long-term cocaine administration, the purpose of the present study was to further evaluate the dose-dependent acute and chronic (27 day) effects of two dose levels of cocaine on the following questions: i) Does chronic cocaine administration decrease food consumption and weight gain?; ii) To what extent does acute or chronic cocaine administration alter body carbohydrate stores (liver and skeletal muscle glycogen content)?; and iii). To what extent does acute or chronic cocaine administration affect plasma glucose and free fatty acid levels and thus hepatic glycogenolysis and adipose tissue lipolysis?



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