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Effect of acute and chronic cocaine administration on food intake, body weight gain and energy substrate homeostasis in rats

Author

Yvette Yi-Wei Xu, University of the Pacific

Date of Award

1990

Document Type

Thesis - Pacific Access Restricted

Degree Name

Master of Science (M.S.)

Department

Graduate Studies

First Advisor

Edward Avakian

First Committee Member

Marvin H. Malone

Second Committee Member

James W. Blankenship

Third Committee Member

Herschel Frye

Abstract

In light of the limited and conflicting experimental data on food intake, body weight change and body energy metabolism following single-dose or long-term cocaine administration, the purpose of the present study was to further evaluate the dose-dependent acute and chronic (27 day) effects of two dose levels of cocaine on the following questions: i) Does chronic cocaine administration decrease food consumption and weight gain?; ii) To what extent does acute or chronic cocaine administration alter body carbohydrate stores (liver and skeletal muscle glycogen content)?; and iii). To what extent does acute or chronic cocaine administration affect plasma glucose and free fatty acid levels and thus hepatic glycogenolysis and adipose tissue lipolysis?

Pages

56

Recommended Citation

Xu, Yvette Yi-Wei. (1990). Effect of acute and chronic cocaine administration on food intake, body weight gain and energy substrate homeostasis in rats. University of the Pacific, Thesis - Pacific Access Restricted. https://scholarlycommons.pacific.edu/uop_etds/2203