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Date of Award
Master of Science (M.S.)
Alice S. Hunter
A laboratory colony of a multi-insecticide susceptible strain of the housefly, Musca domestica was challenged with continuous larval selection pressure equivalent to the initial LC 60 level for 8 generations with the insect growth regulator WL 86303 (1-(3,5-dichloro-4)4-nitrophenoxy- phenyl)-3 -(2)chlorobenzoyl)- urea). A more than twofold increase in resistance was observed at the F8 generation. No cross-tolerance to the related compound, diflubenzuron (DIMILIN (R)) (1-(4-chlorophenyl)-3- (2,6-difluorobenzoyl)-urea) was observed after 8 generations. WL 86303 was significantly less toxic to houseflies than diflubenzuron. No significant difference was noted between the toxicity of WL 86303 to an unpressured wild housefly strain, and to the unselected multi-susceptible strain. A larval-rearing bioassay technique for measuring the toxicity levels of juvenile developmental disruptors is described.
Codrea, Mary Elizabeth. (1982). Experimental induction of resistance to an acylurea insect growth regulator : a thesis .... University of the Pacific, Thesis. https://scholarlycommons.pacific.edu/uop_etds/2072