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Experimental induction of resistance to an acylurea insect growth regulator

Author

Mary Elizabeth Codrea, University of the Pacific

Date of Award

1982

Document Type

Thesis

Degree Name

Master of Science (M.S.)

Department

Graduate Studies

First Advisor

Alice S. Hunter

Second Advisor

James Sanborn

Abstract

A laboratory colony of a multi-insecticide susceptible strain of the housefly, Musca domestica was challenged with continuous larval selection pressure equivalent to the initial LC 60 level for 8 generations with the insect growth regulator WL 86303 (1-(3,5-dichloro-4)4-nitrophenoxy- phenyl)-3 -(2)chlorobenzoyl)- urea). A more than twofold increase in resistance was observed at the F8 generation. No cross-tolerance to the related compound, diflubenzuron (DIMILIN ^(R)) (1-(4-chlorophenyl)-3- (2,6-difluorobenzoyl)-urea) was observed after 8 generations. WL 86303 was significantly less toxic to houseflies than diflubenzuron. No significant difference was noted between the toxicity of WL 86303 to an unpressured wild housefly strain, and to the unselected multi-susceptible strain. A larval-rearing bioassay technique for measuring the toxicity levels of juvenile developmental disruptors is described.

Pages

43

Recommended Citation

Codrea, Mary Elizabeth. (1982). Experimental induction of resistance to an acylurea insect growth regulator. University of the Pacific, Thesis. https://scholarlycommons.pacific.edu/uop_etds/2072