Campus Access Only
All rights reserved. This publication is intended for use solely by faculty, students, and staff of University of the Pacific. No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, now known or later developed, including but not limited to photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author or the publisher.
Date of Award
1980
Document Type
Thesis
Degree Name
Master of Science (M.S.)
Department
Graduate School
First Advisor
Ravindra Vasavada
First Committee Member
Marvin H. Malone
Second Committee Member
Herschel G. Frye
Third Committee Member
Zak Chowhan
Abstract
In the present study lanolin alcohol films were investigated as potential drug delivery systems for the controlled release of salicylic acid. A series of experiments were conducted in vitro to study the release of salicylic acid from these films. The effect of changes in film composition and stirrer speed on drug release were examined. Seven film compositions with varying proportions of lanolin alcohol and ethyl cellulose were prepared over the ethyl cellulose concentrations of 0-30% w/w, while keeping the drug concentration at 2.5% w/w. The release data obtained in this study were examined by the Q vs 1/2 relationship and the first-order relationship. This was done to probe deeper into the underlying mechanism of drug release. Upon examination of the release data by the Q vs 1/2 treatment, it was observed that the correlation coefficients were quite high and lag times were only slightly negative in agreement with the observed initial release data. In contrast, the first-order treatment of data showed somewhat lower correlation coefficients and very high negative lag times. These data strongly suggest that the unidirectional release of salicylic acid from the lanolin alcoholethyl cellulose films follows Higuchi's diffusion-controlled granular matrix model. The release rate constant showed an initial increase with inclusion of ethyl cellulose followed by a sharp decline as the ethyl cellulose concentration was further increased reaching a minimum value at about 15-20 percent of ethyl cellulose. Further increases in the concentration of ethyl cellulose increased the rate of drug release with a tendency to level off at about 30 percent ethyl cellulose concentration. The effect of stirring rate on the release rate constant showed that the rates of release of salicylic acid increased with increases in the stirring rate.
Pages
53
Recommended Citation
Khan, Arshad Rahim. (1980). Release of salicylic acid from lanolin alcohol-ethyl cellulose films. University of the Pacific, Thesis. https://scholarlycommons.pacific.edu/uop_etds/2040
Rights Statement
No Known Copyright. URI: http://rightsstatements.org/vocab/NKC/1.0/
The organization that has made the Item available reasonably believes that the Item is not restricted by copyright or related rights, but a conclusive determination could not be made. Please refer to the organization that has made the Item available for more information. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use.
