Pharmacologic investigation in mice of the effects of narcotic antagonists on dopamine agonist reversal of oxotremorine or reserpine

Author

Mike Minoru Namba, University of the Pacific

Date of Award

1980

Document Type

Thesis

Degree Name

Master of Science (M.S.)

Department

Physiology and Pharmacology

First Advisor

Marvin H. Malone

First Committee Member

James W. Blankenship

Second Committee Member

Katherine K. Knapp

Third Committee Member

Donald Y. Shirachi

Fourth Committee Member

William R. Topp

Fifth Committee Member

Raymond M. Quock

Sixth Committee Member

David S. Fries

Abstract

In the present study, two different drugs were used to induce a Parkinson-like condition. The first drug was the centrally acting cholinergic agonist oxotremorine (OXTM) which readily induces tremor and rigidity in mice (54). This tremor has been reported to be antagonized by dopamine agonists such as L-dopa and apomorphine (50,54,55) as well as by anticholinergic drugs such as scopolamine (46) . The other drug used was reserpine which interferes with the neuronal storage of dopamine and results in its depletion in the brain (56). Reserpine induces tremor, rigidity, blepharoptosis (a drooping of the eyelids), and catalepsy (48,57-59). The catalepsy is readily reversed by the administration of L—dopa (48,60-62). Using these two models of Parkinson's disease, selected narcotic antagonists have been tested to determine if they could potentiate dopaminergic influences and restore the normal balances of acetylcholine and dopamine in the corpus striatum.

Pages

144

Recommended Citation

Namba, Mike Minoru. (1980). Pharmacologic investigation in mice of the effects of narcotic antagonists on dopamine agonist reversal of oxotremorine or reserpine. University of the Pacific, Thesis. https://scholarlycommons.pacific.edu/uop_etds/2038