Date of Award
1980
Document Type
Thesis
Degree Name
Master of Science (M.S.)
Department
Physiology and Pharmacology
First Advisor
Marvin H. Malone
First Committee Member
James W. Blankenship
Second Committee Member
Katherine K. Knapp
Third Committee Member
Donald Y. Shirachi
Fourth Committee Member
William R. Topp
Fifth Committee Member
Raymond M. Quock
Sixth Committee Member
David S. Fries
Abstract
In the present study, two different drugs were used to induce a Parkinson-like condition. The first drug was the centrally acting cholinergic agonist oxotremorine (OXTM) which readily induces tremor and rigidity in mice (54). This tremor has been reported to be antagonized by dopamine agonists such as L-dopa and apomorphine (50,54,55) as well as by anticholinergic drugs such as scopolamine (46) . The other drug used was reserpine which interferes with the neuronal storage of dopamine and results in its depletion in the brain (56). Reserpine induces tremor, rigidity, blepharoptosis (a drooping of the eyelids), and catalepsy (48,57-59). The catalepsy is readily reversed by the administration of L—dopa (48,60-62). Using these two models of Parkinson's disease, selected narcotic antagonists have been tested to determine if they could potentiate dopaminergic influences and restore the normal balances of acetylcholine and dopamine in the corpus striatum.
Pages
144
Recommended Citation
Namba, Mike Minoru. (1980). Pharmacologic investigation in mice of the effects of narcotic antagonists on dopamine agonist reversal of oxotremorine or reserpine. University of the Pacific, Thesis. https://scholarlycommons.pacific.edu/uop_etds/2038
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