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Date of Award


Document Type


Degree Name

Master of Science (M.S.)


Biological Sciences

First Advisor

F. R. Hunter

First Committee Member

W. Michael Kaill

Second Committee Member

Anne Funkhouser


The present kinetic study of the permeability of rabbit erythrocytes has established that carrier systems are involved in the penetration of certain non-electrolytes. Saturation, competitive inhibition, and butanol inhibition kinetics were used to demonstrate the presence of carrier systems and the values of half-saturation constants (ø) were determined for the following water soluble non-electrolytes: glycerol, ethylene glycol, urea, and thiourea.

These non-electrolytes are commonly used in permeability studies because they are relatively non-toxic and their small sizes allow penetration of the erythrocyte membrane within a reasonable length of time.



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