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An investigation of the release of 5-fluorouracil from ointment bases

Author

Vance Leroy Grainger, University of the Pacific

Date of Award

1969

Document Type

Thesis

Degree Name

Master of Science (M.S.)

Department

Pharmacy

First Advisor

James C. King

First Committee Member

Carl C. Riedesel

Second Committee Member

Donald Barker

Third Committee Member

Madhukar Chaubal

Abstract

During the several years in which this therapy has been developed and evaluated, as standard dermatological preparation has not been available. The objective of the present work was to study the release of 5-FU from various ointment bases and to attempt to determine the type of base which would release the compound most satisfactorily.

The methods chosen were designed to determine the release and penetration of 5-FU both by in vitro and in vivo methods. A modified agar plate method was chosen as the in vitro test for measuring release and subsequent diffusion into the agar. The penetration of the compound from various bases was determined by applying the medicated bases to the skin of guinea pigs and subsequently analyzing a biopsy of the inuncted skin, using quantitative spectrophotometry.

Pages

64

Recommended Citation

Grainger, Vance Leroy. (1969). An investigation of the release of 5-fluorouracil from ointment bases. University of the Pacific, Thesis. https://scholarlycommons.pacific.edu/uop_etds/1683