Biomaterials in Mechano-oncology: Means to Tune Materials to Study
Files
Download Full Text
Document Type
Contribution to Book
Book Title
Biomechanics in Oncology
Editor(s)
Cheng Dong, Nastaran Zahir & Konstantinos Konstantopoulos
Description
ECM stiffness is emerging as a prognostic marker of tumor aggression or potential for relapse. However, conflicting reports muddle the question of whether increasing or decreasing stiffness is associated with aggressive disease. This chapter discusses this controversy in more detail, but the fact that tumor stiffening plays a key role in cancer progression and in regulating cancer cell behaviors is clear. The impact of having in vitro biomaterial systems that could capture this stiffening during tumor evolution is very high. These cell culture platforms could help reveal the mechanistic underpinnings of this evolution, find new therapeutic targets to inhibit the cross talk between tumor development and ECM stiffening, and serve as better, more physiologically relevant platforms for drug screening.
Buy Link
https://link.springer.com/chapter/10.1007/978-3-319-95294-9_13
Find in WorldCat
https://worldcat.org/title/1059514051
ISBN
978-3-319-95294-9
DOI
10.1007/978-3-319-95294-9_13
Publication Date
Fall 1-1-2018
Publisher
Springer
City
Cham, Switzerland
First Page
253
Last Page
287
Disciplines
Engineering
Recommended Citation
Peyton, S. R.,
Gencoglu, M.,
Galarza, S.,
&
Schwartz, A. D.
(2018).
Biomaterials in Mechano-oncology: Means to Tune Materials to Study.
In Cheng Dong, Nastaran Zahir & Konstantinos Konstantopoulos (Eds.), Biomechanics in Oncology (253–287). Cham, Switzerland: Springer
https://scholarlycommons.pacific.edu/soecs-facbooks/9
