Associations Between Perceived Stress and Chemotherapy-Induced Peripheral Neuropathy and Otoxicity in Adult Cancer Survivors

Authors

Christine Miaskoski, University of California, San Francisco
Steven M. Paul, University of California, San Francisco
Judy Mastick, University of California, San Francisco
Gary Abrams, University of California, San Francisco
Kimberly Topp, University of California, San Francisco
Betty Smoot, University of California, San Francisco
Kord M. Kober, University of California, San Francisco
Margaret Chesney, University of California, San Francisco
Melissa Mazor, University of California, San Francisco
Grace Mausisa, University of California, San Francisco
Mark Schumacher, University of California, San Francisco
Yvette P. Conley, University of Pittsburgh
Jennifer Henderson Sabes, University of the PacificFollow
Steven Cheung, University of California, San Francisco
Margaret Wallhagen, University of California, San Francisco
Jon D. Levine, University of California, San Francisco

Department

Audiology

Abstract

Context: The most common adverse effects from neurotoxic chemotherapy are chemotherapy-induced neuropathy (CIPN), hearing loss, and tinnitus. Although associations between perceived stress and persistent pain, hearing loss, and tinnitus are documented, no studies have examined these associations in cancer survivors who received neurotoxic chemotherapy.

Objectives: In this cross-sectional study, we evaluated for associations between perceived stress and the occurrence of CIPN, hearing loss, and tinnitus, in 623 adult cancer survivors who received platinum and/or taxane compounds.

Methods: Survivors completed self-report measures of hearing loss, tinnitus, and perceived stress (i.e., Impact of Events Scale—Revised [IES-R]). Separate logistic regression analyses were done for each neurotoxicity to evaluate whether each of the IES-R subscale (i.e., intrusion, avoidance, hyperarousal) and total scores made a significant independent contribution to neurotoxicity group membership.

Results: Of the 623 survivors in this study, 68.4% had CIPN, 34.5% reported hearing loss, and 31.0% reported tinnitus. Older age, higher body mass index, poorer functional status, being born prematurely, cancer diagnosis, and higher intrusion (P = 0.013), hyperarousal (P = 0.014), and total (P = 0.047) IES-R scores were associated with CIPN. Older age, being male, poorer functional status, a worse comorbidity profile, and a higher IES-R hyperarousal (P = 0.007) score were associated with hearing loss. Being male, having less education, a worse comorbidity profile, and a higher IES-R hyperarousal (P = 0.029) score were associated with tinnitus.

Conclusion: These findings suggest that increased levels of perceived stress are associated with the most common chemotherapy-induced neurotoxicities.

Document Type

Article

Publication Date

Summer 7-1-2018

Publication Title

Journal of Pain and Symptom Management

ISSN

0885-3924

Volume

56

Issue

1

DOI

10.1016/j.jpainsymman.2018.02.021

First Page

88

Last Page

97

Recommended Citation

Miaskoski, Christine; Paul, Steven M.; Mastick, Judy; Abrams, Gary; Topp, Kimberly; Smoot, Betty; Kober, Kord M.; Chesney, Margaret; Mazor, Melissa; Mausisa, Grace; Schumacher, Mark; Conley, Yvette P.; Henderson Sabes, Jennifer; Cheung, Steven; Wallhagen, Margaret; and Levine, Jon D., "Associations Between Perceived Stress and Chemotherapy-Induced Peripheral Neuropathy and Otoxicity in Adult Cancer Survivors" (2018). All Faculty Scholarship. 115.
https://scholarlycommons.pacific.edu/shs-all/115