Synthesis and In-vitro Binding Study of NGR Based Peptide Ligands for Targeting CD13/APN
Introduction/Abstract
The CD13, also known as aminopeptidase N (APN), is a 967-residue type-2 cell surface membrane glycoprotein with a number of characteristics of the malignant phenotype such as cell proliferation, secretion, invasion and angiogenesis. Both phage display and in-vivo studies revealed that NGR sequence flanked by at least one amino acid at each end (NGR motif) specifically interacts with CD13. The binding affinity of NGR based peptide ligands towards CD13/Aminopeptidase N (APN) in terms of equilibrium dissociation constants (KD) is currently unknown.
Location
DUC Ballroom A&B
Format
Poster Presentation
Synthesis and In-vitro Binding Study of NGR Based Peptide Ligands for Targeting CD13/APN
DUC Ballroom A&B
The CD13, also known as aminopeptidase N (APN), is a 967-residue type-2 cell surface membrane glycoprotein with a number of characteristics of the malignant phenotype such as cell proliferation, secretion, invasion and angiogenesis. Both phage display and in-vivo studies revealed that NGR sequence flanked by at least one amino acid at each end (NGR motif) specifically interacts with CD13. The binding affinity of NGR based peptide ligands towards CD13/Aminopeptidase N (APN) in terms of equilibrium dissociation constants (KD) is currently unknown.
