NLRX1 modulates the balance between NLRP3 inflammasome activation and NF-kB signaling during Fusobacterium nucleatum infection
Introduction/Abstract
NOD-like receptors (NLRs) play an important role in regulation of host innate immunity, yet their role in periodontitis remains to be defined. NLRX1, a member of the NLR family that localizes to mitochondria, modulates mitochondrial ROS (mROS) generation, which activates the NLRP3 inflammasome. However, the role of NLRX1 in NLRP3 inflammasome activation has not been examined. Therefore, we intend to investigate whether NLRX1 plays a role in NLRP3 inflammasome activation in periodontitis.
Location
DUC Ballroom A&B
Format
Poster Presentation
NLRX1 modulates the balance between NLRP3 inflammasome activation and NF-kB signaling during Fusobacterium nucleatum infection
DUC Ballroom A&B
NOD-like receptors (NLRs) play an important role in regulation of host innate immunity, yet their role in periodontitis remains to be defined. NLRX1, a member of the NLR family that localizes to mitochondria, modulates mitochondrial ROS (mROS) generation, which activates the NLRP3 inflammasome. However, the role of NLRX1 in NLRP3 inflammasome activation has not been examined. Therefore, we intend to investigate whether NLRX1 plays a role in NLRP3 inflammasome activation in periodontitis.
