Naturally occurring molecule, caftaric acid, found in grapes and wine, for use as a transthyretin stabilizing agent
Poster Number
7
Introduction/Abstract
As more attention is raised to transthyretin amyloidosis diseases, molecules that are safe and efficacious are desired for ameliorating their effects.
Purpose
Candidates currently under review have lacked in their efficacy (Tafamidis) or their relative safety (Diflunisal), which leaves patients with few options.
Method
Here we provide evidence that caftaric acid, which is found in high abundance in grapes, raisins, and wine, may be used as a safe and natural transthyretin stabilization agent.
Significance
We present that caftaric acid, at naturally occurring levels in wine and grape juice, binds with high affinity and selectivity in vitro, and attempt to show caftaric acid’s potential as a therapeutic.
Location
DeRosa University Center, Stockton campus, University of the Pacific
Format
Poster Presentation
Naturally occurring molecule, caftaric acid, found in grapes and wine, for use as a transthyretin stabilizing agent
DeRosa University Center, Stockton campus, University of the Pacific
As more attention is raised to transthyretin amyloidosis diseases, molecules that are safe and efficacious are desired for ameliorating their effects.
