EFFICIENT CELLULAR DELIVERY OF METHOTREXATE BY LIPOSOMES CONTAINING NOVEL AMPHIPHILES WITH pH-TRIGGERABLE CONFORMATIONS
Introduction/Abstract
Acid-sensitive liposomes are used as nano-sized vesicles for targeted drug delivery to tumors and inflammation sites. Liposomes are made mostly of lipid molecules with incorporation of other components.
Purpose
Development of a novel type of pH(acid)-sensitive liposomes for targeted drug delivery.
Method
We suggested recently a novel type of pH-sensitive drug delivery system, “fliposomes”, which contain trans-2-aminocyclohexanol-based amphiphiles, “flipids”, that perform a conformational flip (a drastic change of molecular shape) and trigger an instant cargo release in acidic media. Here we report our latest studies on the cellular uptake of the methotrexate-loaded fliposomes.
Results
A series of new flipids has been synthesized, and the cellular uptake in HeLa and B16F1 cancer cells of the methotrexate-loaded fliposomes has been studied.
Significance
New type of acid-sensitive liposomes can serve as viable drug delivery systems in cancer treatment and other areas of medicine.
Location
DeRosa University Center, Stockton campus, University of the Pacific
Format
Poster Presentation
EFFICIENT CELLULAR DELIVERY OF METHOTREXATE BY LIPOSOMES CONTAINING NOVEL AMPHIPHILES WITH pH-TRIGGERABLE CONFORMATIONS
DeRosa University Center, Stockton campus, University of the Pacific
Acid-sensitive liposomes are used as nano-sized vesicles for targeted drug delivery to tumors and inflammation sites. Liposomes are made mostly of lipid molecules with incorporation of other components.
