A Study of the Electrical Activity in Cells
Poster Number
21A
Format
Poster Presentation
Faculty Mentor Name
Carlos Villalba-Galea
Faculty Mentor Department
School of Pharmacy and Health Sciences
Abstract/Artist Statement
Ion channels are proteins on membranes of cells which control the flow of ions in and out of cells. These proteins transition between different formations, called states, due to changing conditions in the cellular environment, including changes in the electrical potential across the membrane and the binding of ligands. In this project, we are working on simulating the transition of ion channels between states. We have started by using a multiple-state sequential and reversible model that applies to any general chemical reaction, and will subsequently add more parameters to make the simulation specific to ion channel behavior. Using matrices to store the data for the population fraction of states and the rate constants governing change between states, we can use matrix multiplication in MatLab to simulate the behavior of the population with respect to time. The work presented here shows our progress to date on simulating the behavior of ion channel proteins.
Location
DeRosa University Center, Ballroom
Start Date
29-4-2017 1:00 PM
End Date
29-4-2017 3:00 PM
A Study of the Electrical Activity in Cells
DeRosa University Center, Ballroom
Ion channels are proteins on membranes of cells which control the flow of ions in and out of cells. These proteins transition between different formations, called states, due to changing conditions in the cellular environment, including changes in the electrical potential across the membrane and the binding of ligands. In this project, we are working on simulating the transition of ion channels between states. We have started by using a multiple-state sequential and reversible model that applies to any general chemical reaction, and will subsequently add more parameters to make the simulation specific to ion channel behavior. Using matrices to store the data for the population fraction of states and the rate constants governing change between states, we can use matrix multiplication in MatLab to simulate the behavior of the population with respect to time. The work presented here shows our progress to date on simulating the behavior of ion channel proteins.