In Vitro Activity of Nucleoside Analogs on the Veterinary Protozoan Parasite Tritrichomonas Foetus
Poster Number
41
Format
Poster Presentation
Faculty Mentor Name
Kirkwood Land
Faculty Mentor Department
Biological Sciences
Abstract/Artist Statement
We carried out a structure activity analysis in Tritrichomonas foetus of a series of adenosine and 7-deazaadenosine analogues. The most potent compounds were found to be the arabino derivatives some of which are potent inhibitors of S-adenosylhomocysteine hydrolase of the human parasite Trichomonas vaginalis. The 9- [2-deoxy-2-azido-β,D-arabinofuranosyl)adenine was found to completely inhibit T. foetus at 10 AμM concentrations with IC50 5 AμM. Of the purine modified antibiotics tested, toyocamycin and formycin completely inhibited T. foetus growth at 100 AμM concentrations with IC50 9.3 AμM and 10.3 AμM, respectively. These analogues may serve as new lead compounds for drug discovery against T. foetus.
Location
DeRosa University Center, Ballroom
Start Date
20-4-2013 1:00 PM
End Date
20-4-2013 3:00 PM
In Vitro Activity of Nucleoside Analogs on the Veterinary Protozoan Parasite Tritrichomonas Foetus
DeRosa University Center, Ballroom
We carried out a structure activity analysis in Tritrichomonas foetus of a series of adenosine and 7-deazaadenosine analogues. The most potent compounds were found to be the arabino derivatives some of which are potent inhibitors of S-adenosylhomocysteine hydrolase of the human parasite Trichomonas vaginalis. The 9- [2-deoxy-2-azido-β,D-arabinofuranosyl)adenine was found to completely inhibit T. foetus at 10 AμM concentrations with IC50 5 AμM. Of the purine modified antibiotics tested, toyocamycin and formycin completely inhibited T. foetus growth at 100 AμM concentrations with IC50 9.3 AμM and 10.3 AμM, respectively. These analogues may serve as new lead compounds for drug discovery against T. foetus.