In Vitro Activity of Calpain Inhibitors Against Tritrichomonas foetus
Poster Number
56
Format
Poster Presentation
Faculty Mentor Name
Kirkwood Land
Faculty Mentor Department
Biological Sciences
Abstract/Artist Statement
Calpains have been shown to have a pathogenic role in many microbial diseases. In this study, we have examined the role of calpain in the in vitro viability of the veterinary protozoal parasite Tritrichomonas foetus. Several calpain inhibitors were tested on the in vitro growth of T. foetus strain D1, the most virulent strain characterized in the laboratory. Although not as potent against T. foetus as other trichomonads, the 50% reduction in viability suggests a important role of these enzymes in viability. This finding warrants further study on role of calpains in the life cycle of this important pathogen.
Location
Grave Covell
Start Date
21-4-2012 10:00 AM
End Date
21-4-2012 12:00 PM
In Vitro Activity of Calpain Inhibitors Against Tritrichomonas foetus
Grave Covell
Calpains have been shown to have a pathogenic role in many microbial diseases. In this study, we have examined the role of calpain in the in vitro viability of the veterinary protozoal parasite Tritrichomonas foetus. Several calpain inhibitors were tested on the in vitro growth of T. foetus strain D1, the most virulent strain characterized in the laboratory. Although not as potent against T. foetus as other trichomonads, the 50% reduction in viability suggests a important role of these enzymes in viability. This finding warrants further study on role of calpains in the life cycle of this important pathogen.