3,4-Dichloroaniline Amides as Anti-trichomonal Agents: Structure Activity Analysis of a Compound Library in vitro
Poster Number
2
Format
Poster Presentation
Faculty Mentor Name
Kirkwood Land
Abstract/Artist Statement
Trichomonas vagina/is is a protozoan that causes the sexually-transmitted disease trichomoniasis in humans. The organism infects both men and women; however, men are asymptomatic, making treatment difficult between partners. Currently, trichomoniasis is one of the most common sexually-transmitted diseases. The current FDA approved treatment is metronidazole. Due to the emergence of clinical drug resistant strains, there is a need to identify alternative chemotherapies. To support this effort, we have screened in vitro a compound library of3,4-dichloroaniline amides. Of the twelve compounds, five were effective at inhibiting parasite growth. IC50 values are currently being determined for these five compounds, as well as structure-activity relationships.
Location
Wendell Phillips Center, 1st floor hallways
Start Date
3-5-2008 1:00 PM
End Date
3-5-2008 3:00 PM
3,4-Dichloroaniline Amides as Anti-trichomonal Agents: Structure Activity Analysis of a Compound Library in vitro
Wendell Phillips Center, 1st floor hallways
Trichomonas vagina/is is a protozoan that causes the sexually-transmitted disease trichomoniasis in humans. The organism infects both men and women; however, men are asymptomatic, making treatment difficult between partners. Currently, trichomoniasis is one of the most common sexually-transmitted diseases. The current FDA approved treatment is metronidazole. Due to the emergence of clinical drug resistant strains, there is a need to identify alternative chemotherapies. To support this effort, we have screened in vitro a compound library of3,4-dichloroaniline amides. Of the twelve compounds, five were effective at inhibiting parasite growth. IC50 values are currently being determined for these five compounds, as well as structure-activity relationships.