Complexes of Re2(O2C2H3)Cl2*2H2O with 1 9-Diethyladenine
Poster Number
11
Format
Poster Presentation
Abstract/Artist Statement
Dimetal carboxylate compounds are proposed to exhibit antitumor activity by reacting with DNA nucleobases. Dirhenium complexes containing a cis-carboxylate core similar to Re2(O2C2H3)2Cl4·2H2O show anticancer properties. These complexes are known to preferentially bind to the purine nucleobases adenine and guanine. To model this reaction, Re2(O2C2H3)2Cl4·2H2O was reacted with a model adenine compound, 1,9- diethyladenine, which is isolated as an iodide salt. Anion exchange reactions were carried out to replace the iodide with different anions (PF6-, BF4-, BPh4-). These salts were reacted with the dirhenium compound, Re2(O2C2H3)2Cl4·2H2O, and the green products were isolated and characterized. UV/visible, IR, and 1H NMR spectroscopic results will be presented.
Location
Pacific Geosciences Center
Start Date
30-4-2005 1:00 PM
End Date
30-4-2005 3:00 PM
Complexes of Re2(O2C2H3)Cl2*2H2O with 1 9-Diethyladenine
Pacific Geosciences Center
Dimetal carboxylate compounds are proposed to exhibit antitumor activity by reacting with DNA nucleobases. Dirhenium complexes containing a cis-carboxylate core similar to Re2(O2C2H3)2Cl4·2H2O show anticancer properties. These complexes are known to preferentially bind to the purine nucleobases adenine and guanine. To model this reaction, Re2(O2C2H3)2Cl4·2H2O was reacted with a model adenine compound, 1,9- diethyladenine, which is isolated as an iodide salt. Anion exchange reactions were carried out to replace the iodide with different anions (PF6-, BF4-, BPh4-). These salts were reacted with the dirhenium compound, Re2(O2C2H3)2Cl4·2H2O, and the green products were isolated and characterized. UV/visible, IR, and 1H NMR spectroscopic results will be presented.