Characterization of dirhenium(III) carboxylate compounds.
Poster Number
4
Format
Poster Presentation
Abstract/Artist Statement
This research study focuses on determining the coordination of the nucleobase 9-ethyladenine with a quadruply bonded dirhenium(III) complex, Re2(O2CCH3)2Cl4•2H2O. The coordination of metals with nucleobases is proposed to be the origin of anticancer activity in some cancer medications. N9 of adenine is substituted to simulate adenine in a natural system where it is attached to the sugar-phosphate backbone of DNA. The nuclear magnetic resonance (NMR) analysis of Re2(O2CCH3)2(9-EtAH)2Cl4 will be discussed. It was originally thought that one N6 hydrogen migrated to N1 during synthesis to facilitate binding but this is not seen in the 1H NMR spectrum. Initial work to obtain crystals of this compound for X-ray analysis was not successful but attempts will be discussed. Anion exchange of chloride ions may enable the isolation of crystalline product. Preliminary results of these exchange products will also be presented.
Location
Pacific Geosciences Center
Start Date
26-4-2003 9:00 AM
End Date
26-4-2003 5:00 PM
Characterization of dirhenium(III) carboxylate compounds.
Pacific Geosciences Center
This research study focuses on determining the coordination of the nucleobase 9-ethyladenine with a quadruply bonded dirhenium(III) complex, Re2(O2CCH3)2Cl4•2H2O. The coordination of metals with nucleobases is proposed to be the origin of anticancer activity in some cancer medications. N9 of adenine is substituted to simulate adenine in a natural system where it is attached to the sugar-phosphate backbone of DNA. The nuclear magnetic resonance (NMR) analysis of Re2(O2CCH3)2(9-EtAH)2Cl4 will be discussed. It was originally thought that one N6 hydrogen migrated to N1 during synthesis to facilitate binding but this is not seen in the 1H NMR spectrum. Initial work to obtain crystals of this compound for X-ray analysis was not successful but attempts will be discussed. Anion exchange of chloride ions may enable the isolation of crystalline product. Preliminary results of these exchange products will also be presented.