Reactivity of dimolybdenum(II) and dirhenium(III) carboxylate compounds with 9-ethyladenine and 1,4,7-triazacyclonane.
Poster Number
19
Format
Poster Presentation
Abstract/Artist Statement
Dinuclear metal carboxylate compounds have been shown to repress tumor growth. It is proposed that the anticancer activity of dinuclear metal systems is a result of their interaction with the purine DNA nucleobases, adenine and guanine. Two possible coordination modes for these ligands are bridging the dinuclear core or chelating to one metal center of the dinuclear core. This study focuses on the chelating coordination mode. Reactions of dimolybdenum(II) and dirhenium(III) carboxylate compounds with 1,4,7-triazacyclonane (TACN) and 9-ethyladenine (9-EtAH) may result in isolation of products containing a chelating nucleobase. The coordinated solvent molecules of [Mo2(02CCH3)2(CH3CN)6][BF4]2 will be replaced by the strongly coordinating tridentate TACN macrocycle and the added 9-EtAH will be forced to chelate to the remaining equatorial metal sites. The reactions of Re2(02CCH3)4Cl2 with TACN and 9-EtAH will also be explored. Preliminary results of newly synthesized compounds will be discussed.
Location
Pacific Geosciences Center
Start Date
20-4-2002 9:00 AM
End Date
20-4-2002 5:00 PM
Reactivity of dimolybdenum(II) and dirhenium(III) carboxylate compounds with 9-ethyladenine and 1,4,7-triazacyclonane.
Pacific Geosciences Center
Dinuclear metal carboxylate compounds have been shown to repress tumor growth. It is proposed that the anticancer activity of dinuclear metal systems is a result of their interaction with the purine DNA nucleobases, adenine and guanine. Two possible coordination modes for these ligands are bridging the dinuclear core or chelating to one metal center of the dinuclear core. This study focuses on the chelating coordination mode. Reactions of dimolybdenum(II) and dirhenium(III) carboxylate compounds with 1,4,7-triazacyclonane (TACN) and 9-ethyladenine (9-EtAH) may result in isolation of products containing a chelating nucleobase. The coordinated solvent molecules of [Mo2(02CCH3)2(CH3CN)6][BF4]2 will be replaced by the strongly coordinating tridentate TACN macrocycle and the added 9-EtAH will be forced to chelate to the remaining equatorial metal sites. The reactions of Re2(02CCH3)4Cl2 with TACN and 9-EtAH will also be explored. Preliminary results of newly synthesized compounds will be discussed.