Title

Exploring the chemistry of dirhenium(III) carboxylate compounds with 9-ethyladenine.

Poster Number

18

Format

Poster Presentation

Abstract/Artist Statement

It has been shown that dinuclear metal carboxylate compounds display antitumor activity; however, the mode of activity is poorly understood. This study involves compounds with a core comprised of two Re(III) metal atoms bridged by cis-carboxylate ligands. This core interacts with the purine nucleobase derivative 9-ethyladenine (9-EtAH) to give compounds that exhibit binding modes that model the binding of dinuclear metal compounds with DNA. Characterization of a recently synthesized dirhenium compound with the proposed formula, Re2(O2CCH3) 2(9EtAH) 2Cl4 will be presented. Also, the preliminary results of the reactions of Re2(02CCH3)2Cl4 with 1,4,7-triazacyclononane and 9-ethyladenine will be discussed.

Location

Pacific Geosciences Center

Start Date

20-4-2002 9:00 AM

End Date

20-4-2002 5:00 PM

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Apr 20th, 9:00 AM Apr 20th, 5:00 PM

Exploring the chemistry of dirhenium(III) carboxylate compounds with 9-ethyladenine.

Pacific Geosciences Center

It has been shown that dinuclear metal carboxylate compounds display antitumor activity; however, the mode of activity is poorly understood. This study involves compounds with a core comprised of two Re(III) metal atoms bridged by cis-carboxylate ligands. This core interacts with the purine nucleobase derivative 9-ethyladenine (9-EtAH) to give compounds that exhibit binding modes that model the binding of dinuclear metal compounds with DNA. Characterization of a recently synthesized dirhenium compound with the proposed formula, Re2(O2CCH3) 2(9EtAH) 2Cl4 will be presented. Also, the preliminary results of the reactions of Re2(02CCH3)2Cl4 with 1,4,7-triazacyclononane and 9-ethyladenine will be discussed.