Abstract
Inflammation is a biological response that, if unregulated, can contribute to various health disorders. The search for new anti-inflammatory agents has led researchers to explore the medicinal potential of Strelitzia reginae, commonly known as the Bird of Paradise. This study aimed to determine the phytochemical composition and anti-inflammatory activity of the methanolic leaf extract of S. reginae. Phytochemical screening confirmed the presence of alkaloids, flavonoids, terpenoids, phenols, saponins, and steroids, while tannins were absent. The Croton Oil-Induced Ear Edema Assay in Swiss albino mice was used to assess anti-inflammatory activity, with Indomethacin as a positive control. Acute oral toxicity testing classified the crude extract as Category 5 under the OECD Guideline 423. Statistical analysis showed that the extract at doses of 25%, 50%, and 75% of LD50 did not exhibit significant anti-inflammatory activity (p > 0.05), whereas Indomethacin demonstrated significant inflammation reduction (p < 0.05). The findings suggest that while S. reginae contains bioactive compounds, its methanolic leaf extract lacks observable anti-inflammatory properties at the tested concentrations. Further studies should explore alternative extraction methods, higher concentrations, or different models to assess its potential therapeutic applications.
Recommended Citation
Hinol, Lyannah Deign Hearty Delantar; De La Cerna, Miflor; Gocela, Decethree; Macalonto, Aymah; and Garay, Junnin Gay
(2025)
"Determination of the Anti-Inflammatory Activity of the Methanolic Leaf Extract of Strelitzia reginae (Strelitziaceae),"
Pacific Journal of Health: Vol. 8:
Iss.
1, Article 13.
DOI: https://doi.org/10.56031/2576-215X.1101
Available at:
https://scholarlycommons.pacific.edu/pjh/vol8/iss1/13
