Abstract: Psoriasis is a prevalent, immune-medication disorder affecting millions of individuals in the United States, leading to substantial healthcare costs (Armstrong, 2021; Brenzinski, 2015). Psoriasis has an established correlation with comorbidities such as hypertension, coronary artery disease, obesity, dyslipidemia, and metabolic syndrome (Al-Mutairi, 2010). Due to the substantial socioeconomic burden psoriatic disease poses on modern day society, significant benefit could be derived from identifying nonprescription strategies for patients to adopt in order to reduce disease activity. This comprehensive review includes 33 publications from 2008 to 2023, evaluating non-prescription therapeutic strategies including lifestyle modification and anti-inflammatory dietary changes. The analysis suggests a positive correlation with reducing psoriatic disease activity by practicing weight loss, adherence to a Mediterranean diet, and gluten avoidance (Di Minno et al., 2014; Phan et al., 2018; Pietzrak, 2017). Further research is needed to provide more robust evidence to establish evidence based medical guidelines with respect to lifestyle and dietary modifications. Psoriatic patients, healthcare professionals, and healthcare systems would collectively benefit from research identifying and evaluating the impact of outside factors on disease severity, such as environmental/dietary exposures with respect to patients’ varied comorbidity status and other baseline demographics.



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