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Life participation approaches to aphasia: international perspectives on communication rehabilitation
Larry Boles and Mimi Lewis
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A guide for Doctor of Pharmacy program assessment
Eric G. Boyce
Assessment activities in higher education are expanding from global institution-wide activities to include specific academic and student service program assessment as a means of improving programs. The assessment movement gained national impetus in the mid 1980s and has continued to expand due to the efforts of assessment experts, institutional and discipline accrediting agencies, professional associations, resource providers, and interested faculty and administrators. The American Association of Colleges of Pharmacy (AACP) has provided leadership and guidance for program assessment and student assessment in pharmacy education through the AACP CAPE Educational Outcomes document,[1] CAPE Handbook on Outcomes Assessment (1995),[2] Background Papers from the Commission to Implement Change in Pharmaceutical Education (1990-1992),[3] and numerous presentations at AACP Annual Meetings and the AACP Institute. The American Council on Pharmaceutical Education (ACPE) has also provided leadership and guidance for program assessment through the ACPE Accreditation Standards and Guidelines.[4-7] Colleges and schools of pharmacy have developed or are developing Pharm.D. program assessment plans and specific assessment methods. A guide and list of resources and examples of assessment plans, methods and tools would be useful to enhance program assessment at colleges and schools of pharmacy.
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Pharmacology and acute toxicity of antirheumatic and immunologic therapy
Eric G. Boyce and Brian F. Mandell
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Hypoxia-selective cellular toxicity of carboranyl-nitroimidazole
John C. Livesey, L. W. Wiens, D. S. Wilbur, D. K. Hamlin, and G. E. Laramore
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Preparation of meta-carboranyl-2-nitroimidazole derivatives for application to BNCT
D. S. Wilbur, D. K. Hamlin, John C. Livesey, R. R. Srivastava, G. E. Laramore, and T. W. Griffin
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Boron neutron capture therapy: a means of increasing the effectiveness of fast neutron radiotherapy
G. E. Laramore, John C. Livesey, P. Wootton, D. S. Wilbur, J. Jacky, R. Risler, and R. Vessella
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Boron neutron capture enhancement of the tumor dose in fast neutron therapy beams
P. Wootton, R. Risler, John C. Livesey, S. Brosard, G. E. Laramore, and T. W. Griffin
The moderation of fast neutron beams by patients’ tissue, combined with developments in tumor affinic boron carriers,1 may allow supplementation of fast neutron beam therapy by boron neutron capture (BNC) reactions. This has the potential to enlarge the “radiation therapeutic window” in some types of tumors, e.g. prostate, and/or permit the development of such a window in the radiation response of others, e.g. brain. The work reported here extends from the studies made by others in fast neutron beams with average energies less than 10 MeV2,3 to beams with average energies up to 24 MeV such as are generated by the p(50.5 MeV) + Be(26MeV) reaction.
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Chemical Protection Against Ionizing Radiation
John C. Livesey, Donald J. Reed, and Lucile F. Adamson
The scientific literature on radiation-protective drugs is reviewed. Emphasis is placed on the mechanisms Involved in determining the sensitivity of biological material to ionizing radiation and mechanisms of chemical radioprotection. In Section 1, the types of radiation are described and the effects of ionizing radiation on biological systems are reviewed. The effects of ionizing radiation are briefly contrasted with the effects of non-Ionizing radiation. Section I reviews the contributions of various natural factors which influence the inherent radiosensitivity of biological systems. Included in the list of these factors are water, oxygen, thiols, vitamins and antioxidants. Brief attention is given to the model describing competition between oxygen and natural radioprotective substances (principally, thiols) In determining the net cellular radiosensitivity. Several theories of the mechanism(s) of action of radioprotective drugs are described In Section 111. These mechanisms include the production of hypoxia, detoxication of radiochemical reactive species, stabilization of the radiobiological target and the enhancement of damage repair processes. Section IV describes the current strategies for the treatment of radiation injury. Likely areas in which fruitful research might be performed are described in Section V. Appendices are devoted to lists of currently-funded research projects Involving chemical radiation protection and a brief compendium of compounds which have been tested for radioprotective activity.
A selection of published books and book chapters from faculty members of the Thomas J. Long School of Pharmacy at University of the Pacific.
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