ORCiD
Adam M. Kaye: 0000-0002-7224-3322
Document Type
Article
Publication Title
Neurology international
ISSN
2035-8385
Volume
14
Issue
1
DOI
10.3390/neurolint14010006
First Page
75
Last Page
88
Publication Date
1-4-2022
Abstract
Hypoactive sexual desire disorder (HSDD) is a persistent deficiency or absence of sexual fantasies and desire resulting in significant distress or interpersonal difficulty. Women with this disorder may display a lack of motivation for sexual activity, reduced responsiveness to erotic cues, a loss of interest during sexual activity, and avoidance of situations that could lead to sexual activity. The pathophysiology of HSDD is thought to be centered around inhibitory and excitatory hormones, neurotransmitters, and specific brain anatomy. Due to the multifactorial nature of HSDD, treatment can be complex and must attempt to target the biological and psychosocial aspects of the disorder. Bremelanotide is a melanocortin receptor agonist and has been recently approved by the FDA to treat HSDD. Bremelanotide is administered intranasally or as a subcutaneous injection. The recommended dosage of bremelanotide is 1.75 mg injected subcutaneously in the abdomen or thigh at least 45 min before sexual activity. Studies showed improvements in desire, arousal, and orgasm scores when 1.75 mg of bremelanotide was administered before sexual activity compared to a placebo. Bremelanotide is a promising way to treat HSDD.
Recommended Citation
Edinoff, A. N.,
Sanders, N. M.,
Lewis, K. B.,
Apgar, T. L.,
Cornett, E. M.,
Kaye, A. M.,
&
Kaye, A. D.
(2022).
Bremelanotide for Treatment of Female Hypoactive Sexual Desire.
Neurology international, 14(1), 75–88.
DOI: 10.3390/neurolint14010006
https://scholarlycommons.pacific.edu/phs-facarticles/602
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
