Immunohistochemical localization of oxidized low-density lipoprotein (OXLDL) and macrophages in coronary arteries: human heart allografts versus human native hearts
Document Type
Article
Publication Title
Journal of Heart Lung Transplant
Volume
20
Issue
2
DOI
10.1016/S1053-2498(00)00388-0
First Page
187
Publication Date
1-1-2001
Abstract
Purpose: The pathogenesis of transplant vascular disease (TVD) is only partly elucidated. We have previously identified and extensively documented prominent intracellular and extracellular accumulation of lipids in the intima and media of coronary arteries from failed human heart allografts. The oxidative status of these lipids, however, remains to be established. We hypothesize that such lipid accumulations are oxidatively modified and that oxLDL contributes to the progression of atheromatous lesions in TVD.
Recommended Citation
McDonald, P. C.,
Huang, Y.,
Steinbrecher, U.,
Lougheed, M.,
Rahimian, R.,
Wong, D.,
Zacher, N.,
Wilson, J.,
&
McManus, B.
(2001).
Immunohistochemical localization of oxidized low-density lipoprotein (OXLDL) and macrophages in coronary arteries: human heart allografts versus human native hearts.
Journal of Heart Lung Transplant, 20(2), 187.
DOI: 10.1016/S1053-2498(00)00388-0
https://scholarlycommons.pacific.edu/phs-facarticles/504
