Document Type
Article
Publication Title
Cell Reports
ISSN
2211-1247
Volume
31
Issue
11
DOI
10.1016/j.celrep.2020.107769
Publication Date
6-16-2020
Abstract
Terminal differentiation is essential for the development and maintenance of tissues in all multi-cellular organisms and is associated with permanent exit from the cell cycle. Failure to permanently exit the cell cycle can result in cancer and disease. However, the molecular mechanisms and timing that coordinate differentiation commitment and cell cycle exit are not yet understood. Using live, single-cell imaging of cell cycle progression and differentiation commitment during adipogenesis, we show that a rapid switch mechanism engages exclusively in G1 to trigger differentiation commitment simultaneously with permanent exit from the cell cycle. We identify a molecular competition in G1 between when the differentiation switch is triggered and when the proliferative window closes that allows mitogen and differentiation stimuli to control the balance between terminally differentiating cells produced and progenitor cells kept in reserve, a parameter of critical importance for enabling proper development of tissue domains and organs. Zhao et al. show that in terminally differentiating cells, a rapid switch mechanism engages exclusively during a G1 period to trigger simultaneous differentiation commitment and permanent cell cycle exit. A molecular competition in each G1 period allows cells to control the balance the terminally differentiating cells produced and progenitor cells kept in reserve.
Recommended Citation
Zhao, M. L.,
Rabiee, A.,
Kovary, K. M.,
Bahrami-Nejad, Z.,
Taylor, B.,
&
Teruel, M. N.
(2020).
Molecular Competition in G1 Controls When Cells Simultaneously Commit to Terminally Differentiate and Exit the Cell Cycle.
Cell Reports, 31(11),
DOI: 10.1016/j.celrep.2020.107769
https://scholarlycommons.pacific.edu/phs-facarticles/448
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
