ORCiD
Adam M. Kaye: 0000-0002-7224-3322
Document Type
Article
Publication Title
Current Pain and Headache Reports
ISSN
1534-3081
Volume
25
Issue
4
DOI
10.1007/s11916-021-00941-8
First Page
1
Last Page
10
Publication Date
3-11-2021
Abstract
PURPOSE OF REVIEW: Opioid use disorder (OUD) remains a national epidemic with an immense consequence to the United States' healthcare system. Current therapeutic options are limited by adverse effects and limited efficacy.
RECENT FINDINGS: Recent advances in therapeutic options for OUD have shown promise in the fight against this ongoing health crisis. Modifications to approved medication-assisted treatment (MAT) include office-based methadone maintenance, implantable and monthly injectable buprenorphine, and an extended-release injectable naltrexone. Therapies under investigation include various strategies such as heroin vaccines, gene-targeted therapy, and biased agonism at the G protein-coupled receptor (GPCR), but several pharmacologic, clinical, and practical barriers limit these treatments' market viability. This manuscript provides a comprehensive review of the current literature regarding recent innovations in OUD treatment.
Recommended Citation
Kuppalli, S.,
Seth, R.,
Orhurhu, V.,
Urits, I.,
Kaye, A. D.,
Hunter, C.,
Gulati, A.,
Adekoya, P.,
Kaye, A. M.,
&
Jones, M. R.
(2021).
Recent Advances in the Treatment of Opioid Use Disorder.
Current Pain and Headache Reports, 25(4), 1–10.
DOI: 10.1007/s11916-021-00941-8
https://scholarlycommons.pacific.edu/phs-facarticles/364
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Included in
Biochemistry, Biophysics, and Structural Biology Commons, Chemicals and Drugs Commons, Pharmacy and Pharmaceutical Sciences Commons
