Chemical approaches to triggerable lipid vesicles for drug and gene delivery
Document Type
Article
Publication Title
Accounts of Chemical Research
ISSN
0001-4842
Volume
36
Issue
5
DOI
10.1021/ar9703241
First Page
335
Last Page
341
Publication Date
3-8-2003
Abstract
Effective drug delivery requires the precise spatial and temporal delivery of therapeutic agents to the target site. To this end, a variety of chemical and physicochemical approaches have been devised to create lipid vesicles (liposomes) that can be triggered to release their contents in a controlled fashion. The triggers include changes in pH, redox potential, temperature, or the level of specific enzymes. We review the chemistries that have recently been applied to exploit the pH and redox potential triggers so as to release vesicle contents in the appropriate biological location.
Recommended Citation
Guo, X.,
&
Szoka, F. C.
(2003).
Chemical approaches to triggerable lipid vesicles for drug and gene delivery.
Accounts of Chemical Research, 36(5), 335–341.
DOI: 10.1021/ar9703241
https://scholarlycommons.pacific.edu/phs-facarticles/297
