The effect of rifampin on theophylline kinetics
ORCiD
0000-0002-5447-9016
Document Type
Article
Publication Title
Journal of Clinical Pharmacology
ISSN
0091-2700
Volume
26
Issue
8
DOI
10.1002/j.1552-4604.1986.tb02975.x
First Page
696
Last Page
699
Publication Date
11-1-1986
Abstract
The effect of rifampin on the pharmacokinetics of theophylline was studied in ten healthy nonsmoking men (age, 23–42 years). Each subject received 5.9-6.8 mg/kg of aminophyl-line intravenously over 20 minutes before and at the end of two weeks of oral rifampin therapy (600 mg/d). Theophylline serum concentrations were measured serially over the 24 hours following each aminophylline infusion. In every subject, rifampin caused an increase in total clearance (from 0.88 ± 0.21 to 1.21 ± 0.29 mL/min/kg) and terminal elimination rate constant (from 0.104 ± 0.023 to 0.148 ± 0.030 hr−1) and a decrease in the area under the theophylline concentration-time curve (from 104 ± 29 to 76 ± 19 hr-mg/L) and half-life of theophylline (from 7.0 ± 1.7 to 4.8 ± 0.9 hr). All of these changes were significant (P < .02, Wilcoxon matched-pair, signed-rank, two-tailed test). The apparent volume of distribution of theophylline did not consistently change following rifampin administration (mean change, −4%; range, −18-+20%, P > .20). Patients should be monitored for signs of decreased theophylline efficacy when rifampin is added, or of increased theophylline toxicity when rifampin is discontinued from maintanence therapy.
Recommended Citation
Boyce, E. G.,
Dukes, G. E.,
Rollins, D. E.,
&
Sudds, T. W.
(1986).
The effect of rifampin on theophylline kinetics.
Journal of Clinical Pharmacology, 26(8), 696–699.
DOI: 10.1002/j.1552-4604.1986.tb02975.x
https://scholarlycommons.pacific.edu/phs-facarticles/259
