Delay or inhibition of rat lens opacification using pantethine and WR77913
ORCiD
0000-0001-9010-5970
Document Type
Article
Publication Title
Experimental Eye Research
ISSN
0014-4835
Volume
62
Issue
1
DOI
10.1006/exer.1996.0009
First Page
75
Last Page
84
Publication Date
1-1-1996
Abstract
Pantethine and the amino phosphorothioate, WR-77913, protected lenses against increased light scattering and opacification during cataract formation in five animal models: (1) radiation, (2) selenite, (3) galactose, (4) streptozotocin and (5) Royal College of Surgeons. In the radiation or selenite models, each test reagent was administered 15 to 30 min prior to initiation of cataract by a single injection of Na2SeO3 or a single exposure to 15 Gy (gray) gamma radiation. In the galactose, streptozotocin and Royal College of Surgeons models where the cataractogenic insult was continuous, repeated administrations of pantethine and WR-77913 were necessary. The results suggested that protein aggregation and lens opacification associated with a variety of physiological and biochemical mechanisms can be delayed or inhibited using a systemic administration of pantethine or WR-77913.
Recommended Citation
Clark, J. I.,
Livesey, J. C.,
&
Steele, J. E.
(1996).
Delay or inhibition of rat lens opacification using pantethine and WR77913.
Experimental Eye Research, 62(1), 75–84.
DOI: 10.1006/exer.1996.0009
https://scholarlycommons.pacific.edu/phs-facarticles/206
