Patent Number
WO2017066132A2
Date Applied
October 2016
Date Approved
4-20-2017
Agency
World Intellectual Property Organization, Patent Cooperation Treaty - United Nations
Status
Published
Abstract
The present disclosure relates to compositions and methods comprising peptide molecules that mimic the binding and functional properties of native antibodies relative to their respective targets. Some embodiments comprise peptide-drug conjugates (PDCs) comprising the mimic peptides disclosed herein. The targets of these mimic peptides include epidermal growth factor receptor (EGFR), and human epidermal growth factor receptor 2 (HER2), vascular endothelial growth factor (VEGF), programmed cell death protein 1 (PD-1), and programmed death-ligand 1 (PD-L1). The present disclosure comprises application of the knob-socket computational model to design antibody mimics for proteins.
Link to Patent
https://patents.google.com/patent/WO2017066132A2/en?
Recommended Citation
Jasti, Bhaskara; Li, Xiaoling; Tsai, Jerry W.; Joo, Hyun; Zheng, Yu; and Sachdeva, Sameer, "Synthetic Antibody Mimic Peptides" (2017). Pacific Patents. 6.
https://scholarlycommons.pacific.edu/patents/6
