Synthetic Antibody Mimic Peptides

Patent Number

WO2017066132A2

Inventors

Bhaskara Jasti, University of the PacificFollow
Xiaoling Li, University of the PacificFollow
Jerry W. Tsai, University of the PacificFollow
Hyun Joo
Yu Zheng
Sameer Sachdeva

Date Applied

October 2016

Date Approved

4-20-2017

Agency

World Intellectual Property Organization, Patent Cooperation Treaty - United Nations

Status

Published

Abstract

The present disclosure relates to compositions and methods comprising peptide molecules that mimic the binding and functional properties of native antibodies relative to their respective targets. Some embodiments comprise peptide-drug conjugates (PDCs) comprising the mimic peptides disclosed herein. The targets of these mimic peptides include epidermal growth factor receptor (EGFR), and human epidermal growth factor receptor 2 (HER2), vascular endothelial growth factor (VEGF), programmed cell death protein 1 (PD-1), and programmed death-ligand 1 (PD-L1). The present disclosure comprises application of the knob-socket computational model to design antibody mimics for proteins.

Link to Patent

https://patents.google.com/patent/WO2017066132A2/en?

Recommended Citation

Jasti, Bhaskara; Li, Xiaoling; Tsai, Jerry W.; Joo, Hyun; Zheng, Yu; and Sachdeva, Sameer, "Synthetic Antibody Mimic Peptides" (2017). Pacific Patents. 6.
https://scholarlycommons.pacific.edu/patents/6