The notochord and epidermis help pattern the neural tube

Creator

Ajna S. Rivera, University of the PacificFollow
Amanda Lo, University of the Pacific

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Creation Date

2019

Description

Opposing gradients pattern the neural tube. TGFbs (blue) from the epidermis and Sonic Hedgehog (Shh, red) from the notochord pattern the dorsal/ventral axis of the neural tube. Neurons exposed to a high concentration of TGFbs will become sensory neurons, those exposed to high levels of Shh will become motor neurons. Neurons exposed to low levels of both will become interneurons. Figure by Amanda Lo and Ajna Rivera

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