Even-skipped regulation

Creator

Ajna S. Rivera, University of the PacificFollow
Lo Amanda, University of the Pacific

Preview

Creation Date

2019

Description

Grey shapes are denticle bands (bristles) found in each abdominal segment. The Kruppel mutant has lost 6 of these bands, corresponding with Kruppel expression over the first 6 abdominal segments.

Comments

The even-skipped gene is expressed in 7 stripes along the A/P axis. It has 4 major cis-regulatory enhancers that control this. One element controlling stripes 3 and 7 has binding sites for Hunchback and Knirps, both of which repress the expression driven by the 3+7 enhancer. This enhancer is activated by the ubiquitous (expressed everywhere) activator Zelda. The element controlling stripe 2 is even more complex with binding sites for Bicoid, Hunchback, Caudal, Kruppel, and Knirps.

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